A Guide to Female Sexual Dysfunction Treatments

Apply the cream with your finger 10 to 15 minutes before sexual activity up to once per day.

Brand/Type	Average Cost per Dose (£)	Over a Month (£)	Availability in Pharmacies	Notes
Enhancify	4-6	120-180	Limited	Prescription required
Online Supplements	3-5	90-150	Online only	Check authenticity
Off-label Sildenafil	2-4	60-120	Local pharmacies	Off-label use caution

Slowly squeeze out a length of cream about 2 ½ inches long for one 2-gram dose. Lying on your back, apply half the cream on and around the clitoris and the area around the vaginal opening, avoiding areas with hair. Apply the rest of the cream just inside the vagina, rubbing the cream with a curved finger on the front wall of the vagina.

Do They Work?

Talk with your provider to see if DARE to PLAY is right for you. Bring this prescribing guide to your visit: Right now, you can get a prescription for DARE to PLAY — even though you cannot place an order yet. Sildenafil (the active ingredient in Viagra®) has been proven for decades to increase blood flow. DARE to PLAY Sildenafil Cream uses the same trusted ingredient in a targeted topical formula designed for the unique anatomy of the female genitals. It works by helping blood vessels in the clitoris and vulva relax and open, allowing increased blood flow – resulting in: Warmth, swelling, tingling/throbbing, and sensitivity in the genital area It has been shown to increase blood flow within 10-15 minutes after application.

Let's do it.

We also got busy with a full clinical study of 200 women experiencing symptoms of FSAD. Getting powerful ingredients like sildenafil through the skin isn’t easy – most drugs carry an electrical charge, and the skin’s outer layer (called the stratum corneum) is built to keep them out. That’s where DermaFlux™, a cutting-edge topical drug delivery system, comes in. This advanced cream technology helps deliver sildenafil deep into the tissues that matter for sexual arousal. The cream uses special salts—tri-sodium citrate and potassium chloride—to helppush the active ingredient through theskin’s toughest layer.

Top What Is Natural Viagra for Females Related Articles

Normally, drugs can stick to the skin’ssurface due to hydrogen bonding. Thehigh salt content in this cream helpsprevent that stickiness, allowingsildenafil to penetrate deeper into thetissue. The cream’s design includes bothwater-loving (hydrophilic) and oil-loving (hydrophobic) regions. This uniquestructure helps the cream interact withdifferent skin layers, ensuring the druggets where it needs to go. The cream uses special salts—tri-sodium citrate and potassiumchloride—to help push the activeingredient through the skin’stoughest layer. Once applied, do not wipe off any of the cream until after sexual activity.

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In the Phase 2b clinical study, women did not use lubricants because the study was specifically designed to evaluate the impact of DARE to PLAY on the genital arousal response.

HOW TO GET YOUR PRESCRIPTION

The safety findings from the Phase 2b clinical study have been published and are available on the DARE to PLAY website. If you experience difficulty with sexual arousal, including a lack of physical response or reduced genital sensitivity during sexual activity, you may benefit from DARE to PLAY. A conversation with a licensed healthcare provider can help determine whether it is appropriate for you. DARE to PLAY contains the same active ingredient as Viagra®, but it’s formulated specifically for women and applied directly where it’s needed. Unlike an oral pill, DARE to PLAY is a topical cream designed to work locally rather than systemically. However, there are no concerns about the compatibility of lubricants with the DARE to PLAY formulation. DARE to PLAY has been studied in both pre-and postmenopausal women to evaluate safety, tolerability, and how the drug is absorbed in the body (pharmacokinetics). In these studies, the cream was well tolerated.

• Research is ongoing into new drug targets, like melanocortins and oxytocin.
• Lybrido and Lybridos were combination drugs (testosterone/sildenafil) investigated.
• The EROS-CTD device is an example of a non-hormonal, device-based treatment.
• Gene therapy and other novel approaches are in very early stages of research.
• Future treatments may offer more personalized approaches based on individual biology.
• Digital therapeutics and app-based cognitive behavioral therapy are emerging.
• The field is moving towards treating the combined psychological and biological causes.

The Phase 2b clinical study enrolled healthy pre-and perimenopausal women aged 18 to 45 who had a diagnosis of Female Sexual Arousal Disorder (FSAD). Similar to FDA-approved products for Hypoactive Sexual Desire Disorder viagra tablet sex (HSDD), FSAD trials conducted for FDA review typically focus on either pre-or postmenopausal populations.

Side Effect	Percentage of Users	Severity	Notes
Nausea	15%	Mild	Usually mild, transient
Headache	20%	Mild to Moderate	Common among users
Dizziness	10%	Mild	Typically subsides
Insomnia	8%	Mild	Reported in some cases

In the Phase 2b clinical study, approximately one-third of the participants were taking an SSRI. An informal analysis compared women on SSRIs with those who were not and found that both groups showed positive trends in improved arousal sensations. Many vaginal products contain ingredients that can weaken condoms, increasing the risk of breakage. DARE to PLAY was tested using ASTM D7661-10, a standardized method that ensures a product is safe to use with condoms. Based on these tests, DARE to PLAY is compatible with all male condoms except those made of polyurethane. In the Phase 2b clinical study, women were allowed to use DARE to PLAY during oral sex, and it was well tolerated with no significant safety concerns. Prior to the Phase 2b clinical study, DARE to PLAY was also tested in a preclinical study to assess its effects on the oral mucosa.

Trend	Description	Expected Developments
Increased regulatory approval	More medications gaining approval	Expanded options for women
Personalized treatment plans	Based on genetic and hormonal profiles	Customized therapies
Natural and organic products	Growing popularity among health-conscious consumers	Rise of herbal and plant-based solutions

These tests showed that daily exposure for 28 days did not cause irritation inside the mouth. The DARE to PLAY formulation does contain a proprietary combination of salts that support the absorption of sildenafil into the tissue. As a result, you may notice a mildly salty taste. DARE to PLAY can be used in both situations!

• Vaginal moisturizers (e.g., Replens) provide long-lasting relief from dryness.
• Vaginal lubricants (e.g., Sylk, YES) reduce friction and discomfort during intercourse.
• Topical estrogen creams (e.g., Vagifem) locally treat vaginal atrophy and dryness.
• Pelvic floor physical therapy can improve muscle tone and blood flow to the pelvis.
• Sex therapy focuses on improving intimacy and communication with a partner.
• Mindfulness and sensate focus exercises can help reduce performance anxiety.
• Devices like the Eros-Clitoral Therapy Device use gentle suction to increase blood flow.

In the Phase 2b clinical study, about 20% of sexual events were solo, and women reported that these experiences were often more satisfying than partnered events. Partnered events sometimes occurred under less-than-ideal conditions, like limited time or distractions, which can affect pleasure. DARE to PLAY is designed to complement, not replace, other approaches. It is a pharmacologic option focused on improving genital blood flow and physical responsiveness.

What women are saying

The results were published in the Green Journal (Obstetrics & Gynecology), the official journal of the American College of Obstetricians and Gynecologists (ACOG) and highlighted on ACOG’s podcast The Green Room. Clinical trial results were also featured in The Journal of Sexual Medicine, the official journal of the International Society for the Study of Women’s Sexual Health. DARE to PLAY is the only sildenafil cream for women supported by published, peer-reviewed clinical data. It was studied in clinical trials that used clinically validated and FDA-reviewed endpoints to measure results. The cream is designed with a proprietary drug delivery system that helps sildenafil get into the vaginal and vulvar tissue, where it can act locally to increase blood flow.

What causes low libido in women?

Other sildenafil creams on the market haven’t been proven to work–they have not been studied, shown to absorb properly or published in peer-reviewed research, and are often compounded without consistent quality standards. DARE to PLAY stands apart because it’s rigorously developed, science-backed, and held to the highest standards of quality and clinical evidence. Sildenafil (the active ingredient in Viagra®) has a long-established safety profile in men. The topical formulation used in DARE to PLAY is designed to work locally (in the tissues that matter for sexual arousal) while minimizing how much of the drug enters the bloodstream. DARE to PLAY has been evaluated in clinical studies and was well tolerated, with no significant safety concerns reported. Women often benefit most from a multimodal approach. DARE to PLAY is designed to improve physical arousal by increasing genital blood flow. Many women find that enhancing physical responsiveness can also help restore desire and confidence.

• A healthy, balanced diet supports overall health, including hormonal balance.
• Regular physical exercise improves blood circulation, mood, and body image.
• Adequate sleep is crucial for regulating hormones that influence sexual desire.
• Stress management techniques (yoga, meditation) can reduce a major libido killer.
• Reducing alcohol consumption can improve sexual response and overall health.
• Quitting smoking improves blood flow to sexual organs and overall vitality.
• Open communication with a partner is fundamental for a healthy sexual relationship.

In the Phase 2b clinical study, women with low desire due to diminished physical arousal sensations experienced improved desire following use of DARE to PLAY.

How DARE to PLAY Sildenafil Cream Works

Normally, drugs can stick to theskin’s surface due to hydrogenbonding. The high salt content inthis cream helps prevent thatstickiness, allowing sildenafil topenetrate deeper into the tissue. Thisunique structure helps the creaminteract with different skin layers,ensuring the drug gets where itneeds to go. May not penetrate into the epithelial tissue When it comes to your body and your health, consistency and safety aren’t optional – they are essential. You deserve a product that has been clinically studied, carefully formulated, and made to the highest safety and quality standards.

What are other tips for boosting female sex drive?

With DARE to PLAY Sildenafil Cream, you can feel confident in what you’re using – every single time. This is the first clinical study of its kind to demonstrate that this specific topical formulation of sildenafil, DARE to PLAY Sildenafil Cream, can support genital blood flow and arousal in women. Offering a non-hormonal option with a faster onset (10–15 minutes) and fewer side effects than oral medications, it represents a significant breakthrough for female sexual health. Daré’s proprietary formulation of Sildenafil Cream was evaluated in the RESPOND Study, the first-ever randomized, double-blind, placebo-controlled clinical trial for a topical treatment targeting Female Sexual Arousal Disorder (FSAD) submitted to the FDA. This Phase 2b trial included 200 premenopausal women experiencing symptoms of FSAD, such as reduced genital sensation and frustration during intimacy.

Interactions with other medications

Safety Profile: The side effect profile of DARE to PLAY Sildenafil Cream was similar to placebo (cream without sildenafil added), with no serious safety concerns reported. Study Results:Women using DARE to PLAY Sildenafil Cream experienced the following improvements, as measured by clinically validated and FDA-reviewed endpoints: Reduced feelings of sexual distress and interpersonal difficulties resulting from the sexual difficulties In the Phase 2b trial, after 12 weeks, women who used DARE to PLAY Sildenafil Cream reported statistically significant and clinically meaningful improvements in genital arousal sensation (warmth and tingling) compared to those who used placebo cream. On average, Arousal Sensation scores (measured by a patient-reported questionnaire) increased by over 2 points with DARE to PLAY Sildenafil Cream, compared to almost no change with placebo cream. Women who used DARE to PLAY Sildenafil Cream also showed improvement across other key areas of sexual function, including desire and orgasm. Results shown are from a subset of 65 women in a buy soft viagra 12-week clinical trial: 33 women who received Sildenafil Cream and 32 who received Placebo Cream.