Vardenafil 20 mg in Patients with Underlying Conditions
Vardenafil is available as 2.5mg, 5mg, 10mg, or 20mg (milligrams) oral tablets. It’s also sold as disintegrating tablets under the brand name Staxyn®. Vardenafil pills are designed to be taken about an hour before sexual activity. You can take it with or without food, but it might work more quickly if you take it on an empty stomach.
- Vardenafil is sometimes used off-label for pulmonary arterial hypertension.
- Use caution when combining with other vasodilators or certain antidepressants.
- The drug is often prescribed after diagnosis of erectile dysfunction by a clinician.
- It’s essential to follow the prescribed course and not self-medicate.
The effects can last five to seven hours, making vardenafil a great choice for single-night use compared to longer-acting ED medications.
Schedule A Consultation
Use the PDF linked in the document sidebar for the official electronic format. The Food and Drug Administration (FDA or Agency) has determined that Levitra (vardenafil hydrochloride) oral tablets, 5 milligrams (mg), 10 mg, and 20 mg, were not withdrawn from sale for reasons of safety or effectiveness. This determination means that FDA will not begin procedures to withdraw approval of abbreviated new drug applications (ANDAs) that refer to these drug products, and it will allow FDA to continue to approve ANDAs that refer to these products as long as they meet relevant legal and regulatory requirements. Daniel Ritterbeck, Center for Drug Evaluation and Research, Food and Drug Administration, 10903 New Hampshire Ave., Bldg. Section 505(j) of the Federal Food, Drug, and Cosmetic Act (FD&C Act) (21 U.S.C.
Key differences between Cialis and Levitra
355(j)) allows the submission of an ANDA to market a generic version of a previously approved drug product. To obtain approval, the ANDA applicant must show, among other things, that the generic drug product: (1) has the same active ingredient(s), dosage form, route of administration, strength, conditions of use, and (with certain exceptions) labeling as the listed drug, which is a version of the drug that was previously approved, and (2) is bioequivalent to the listed drug. ANDA applicants do not have to repeat the extensive clinical testing otherwise necessary to gain approval of a new drug application (NDA). Section 505(j)(7) of the FD&C Act requires FDA to publish a list of all approved drugs. FDA publishes this list as part of the “Approved Drug Products With Therapeutic Equivalence Evaluations,” which is known generally as the “Orange Book.” Under FDA regulations, drugs are removed from the list if the Agency withdraws or suspends approval vardenafil premature ejaculation of the drug's NDA or ANDA for reasons of safety or effectiveness or if FDA determines that the listed drug was withdrawn from sale for reasons of safety or effectiveness (21 CFR 314.162).
2.4 Statistical considerations
A person may petition the Agency to determine, or the Agency may determine on its own initiative, whether a listed drug was withdrawn from sale for reasons of safety or effectiveness. This determination may be made at any time after the drug has been withdrawn from sale, but must be made prior to approving an ANDA that refers to the listed drug (§ 314.161 (21 CFR 314.161)). FDA may not approve an ANDA that does not refer to a listed drug. Levitra (vardenafil hydrochloride) oral tablets, 5 mg, 10 mg and 20 mg, are ( printed page 27902) the subject of NDA 021400, held by Bayer HealthCare Pharmaceuticals, Inc., and initially approved on August 19, 2003. Levitra is a phosphodiesterase 5 inhibitor indicated for the treatment of erectile dysfunction. Our blog on Levitra versus Viagra compares vardenafil to another single-night-use ED medication. Serious side effects from vardenafil and other ED medications are uncommon, only affecting a small percentage of men who use them.
| Product | Dosage | Quantity + Bonus | Price | |
|---|---|---|---|---|
| Viagra Original | 100mg | 48 + 4 Pills | 207.15€ 197.29€ | |
| Cialis Generic | 5mg | 360 + 10 Pills | 268.08€ 255.31€ | |
| Cialis Original | 20mg | 48 + 4 Pills | 224.69€ 213.99€ | |
| Cialis Generic | 60mg | 120 + 8 Pills | 240.18€ 228.74€ | |
| Kamagra | 100mg | 360 + 6 Pills | 839.95€ 799.95€ | |
| Viagra Generic | 150mg | 360 + 10 Pills | 423.48€ 403.31€ | |
| Viagra Generic | 200mg | 90 + 6 Pills | 170.79€ 162.66€ | |
| Cialis Soft Tabs | 20mg | 10 Pills | 39.03€ 37.17€ | |
| Kamagra Soft Tabs | 100 mg | 20 Pills | 79.79€ 75.99€ | |
| Cialis Generic | 2.5mg | 60 + 4 Pills | 83.43€ 79.46€ | |
| Levitra Generic | 10mg | 60 + 6 Pills | 112.98€ 107.60€ | |
| Cialis Generic | 10mg | 90 + 6 Pills | 146.17€ 139.21€ | |
| Levitra Professional | 20mg | 270 + 6 Pills | 738.98€ 703.79€ | |
| Viagra Original | 100mg | 22 + 2 Pills | 120.71€ 114.96€ | |
| Cialis Generic | 10mg | 20 Pills | 48.23€ 45.93€ | |
| Kamagra Polo | 100 mg | 272 + 12 Pills | 622.94€ 593.28€ | |
| Viagra Professional | 100mg | 180 + 4 Pills | 337.30€ 321.24€ |
However, they can still happen, and some may require urgent medical attention when they occur. Let’s go over the more serious potential side effects and drug interactions of vardenafil, including those that call for medical help. Priapism is a painful, prolonged erection lasting four hours or longer.
How should this medicine be used?
Additional ANDAs for these drug products may also be approved by the Agency as long as they meet all other legal and regulatory requirements for the approval of ANDAs. If FDA determines that labeling for these drug products should be revised to meet current standards, the Agency will advise ANDA applicants to submit such labeling. Vardenafil (generic for Levitra®) improves erectile dysfunction (ED) by making it easier for blood to flow to the penis. It’s in the same class of drugs as Viagra®, Cialis®, and Stendra®, and like these other medications for ED, vardenafil is safe and effective when taken as prescribed. However, there are potential vardenafil side effects to consider, like headaches and nausea. It happens when blood can’t flow out of the penis after an erection.
5 Conclusion
In letters dated September 26, 2019, September 24, 2020, and September 20, 2021, Bayer HealthCare Pharmaceuticals, Inc. notified FDA that Levitra (vardenafil hydrochloride) oral tablets, 5 mg, 10 mg and 20 mg, respectively, were being discontinued, and FDA moved the drug products to the “Discontinued Drug Product List” section of the Orange Book. Respira Therapeutics, Inc. submitted a citizen petition dated August 29, 2022 (Docket No. FDA-2022-P-2060), under 21 CFR 10.30, requesting that the Agency determine whether Levitra (vardenafil hydrochloride) oral tablets, 20 mg, were withdrawn from sale for reasons of safety or effectiveness.
Legal Class
Although the citizen petition did not address the 5 mg and 10 mg strengths, those strengths have also been discontinued. On our own initiative, we have also determined whether those strengths were withdrawn for safety or effectiveness reasons. After considering the citizen petition and reviewing Agency records and based on the information we have at this time, FDA has determined under § 314.161 that Levitra (vardenafil hydrochloride) oral tablets, 5 mg, 10 mg, and 20 mg, were not withdrawn for reasons of safety or effectiveness. The petitioner has identified no data or other information suggesting that these drug products were withdrawn for reasons of safety or effectiveness. We have carefully reviewed our files for records concerning the withdrawal of Levitra (vardenafil hydrochloride) oral tablets, 5 mg, 10 mg, and 20 mg, from sale.
Does vardenafil interact with foods or drinks?
We have also independently evaluated relevant literature and data for possible postmarketing adverse events. We have reviewed the available evidence and determined that these drug products were not withdrawn from sale for reasons of safety or effectiveness. Accordingly, the Agency will continue to list Levitra (vardenafil hydrochloride) oral tablets, 5 mg, 10 mg, and 20 mg, in the “Discontinued Drug Product List” section of the Orange Book. The “Discontinued Drug Product List” delineates, among other items, drug products that have been discontinued from marketing for reasons other than safety or effectiveness. FDA will not begin procedures to withdraw approval of approved ANDAs that refer to these drug products. When untreated, priapism can damage erectile tissues inside the penis. There have been rare reports of priapism from all medications used to treat erectile dysfunction, including vardenafil. Still, priapism is a serious medical issue.
- 20 mg vardenafil is considered a standard starting dose for many men.
- Consult a doctor if you experience prolonged or painful erections.
- Vardenafil is a phosphodiesterase inhibitor that promotes vasodilation.
- Do not crush or break the vardenafil tablets; take them whole.
If you get an erection that lasts four or more hours after using vardenafil, seek medical assistance immediately.
| Reported Benefits | Common Feedback | Additional Notes |
|---|---|---|
| Improved erectile function | Yes, reported by 75-85% of users | Effective within 30-60 minutes |
| Quick onset | Many users notice rapid effects | Fast-acting profile |
| Few side effects | Mild headaches and flushing common | Well tolerated in most cases |
| Duration of effect | Varies from 4 to 6 hours | Consultation for personalized advice |
Priapism can be treated successfully in a hospital, helping you avoid lasting damage to the erectile tissues of your penis.
What are the main differences between Levitra and Cialis?
88 FR 38230 FR 78782024-13208USDA09/05/24RULE0503-AA39SORN Choosing an item from full text search results will bring you to those results. Pressing enter in the search box will also bring you to search results. Choosing an item from suggestions will bring you directly to the content. Determination That Levitra (Vardenafil Hydrochloride) Oral Tablets, 5 Milligrams, 10 Milligrams, and 20 Milligrams, Were Not Withdrawn From Sale for Reasons of Safety or Effectiveness This table of contents is a navigational tool, processed from the headings within the legal text of Federal Register documents. This repetition of headings to form internal navigation links has no substantive legal effect.
Other Interactions
FederalRegister.gov retrieves relevant information about this document from Regulations.gov to provide users with additional context. This information is not part of the official Federal Register document. Requests that the FDA determine whether LEVITRA® (vardenafil HCl) 20 mg tablets approved under New Drug Application (NDA) 021400 and held by Bayer Healthcare Pharmaceuticals Inc. has been withdrawn for reasons of safety or effectiveness; CLOSED Document page views are updated periodically throughout the day and are cumulative counts for this document. Counts are subject to sampling, reprocessing and revision (up or down) throughout the day.
Who Should Not Take Viagra™
2,287 as of 05/28/2026 at 6:15 am EDT This document is also available in the following formats: 2023-09365 as it appeared on Public Inspection on 05/02/2023 at 8:45 am. It was viewed 13 times while on Public Inspection. If you are using public inspection listings for legal research, you should verify the contents of the documents against a final, official edition of the Federal Register. Only official editions of the Federal Register provide legal notice of publication to the public and judicial notice to the courts under 44 U.S.C. Published Document: 2023-09365 (88 FR 27901) This document has been published in the Federal Register. Vardenafil and other ED medications are linked to cases of optic nerve damage causing decreased vision. Vision changes are a very uncommon side effect of PDE5 inhibitors.
What is vardenafil?
While most adverse effects are mild, some may be more serious. We’ll list the common and uncommon side effects of vardenafil and what you can do to deal with them and improve your experience while using this medication for ED. These drugs increase blood flow to erectile tissues in the penis, making it easier to get and keep an erection with sexual stimulation. It’s one of several medications for ED. Others include sildenafil (the active ingredient in Viagra), tadalafil (Cialis), and avanafil (Stendra). If you experience sudden vision loss in one or both eyes after using vardenafil, seek medical attention immediately. Vision loss could be a sign of non-arteritic anterior ischemic optic neuropathy (NAION).